Jakob Magolan, PhD

Jakob Magolan, PhD

Associate Professor,
Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences

Boris Family Chair in Drug Discovery
Joint Member, Chemistry and Chemical Biology

MDCL 2306
McMaster University
magolanj@mcmaster.ca
905-525-9140 ext. 22268

Research

  • Pre-Clinical Drug Discovery and Development
  • Organic Synthetic Methods

In collaboration with biologists and biochemists, we pursue the discovery and pre-clinical development of pharmaceutical leads in a variety of therapeutic areas including: antimicrobial, anti-pancreatic cancer, and anti-depression. We specialize in the chemical synthesis of lead compounds and their structural derivatives with a particular interest in natural product-based leads.

Our laboratory is also engaged in the development new strategies and methodologies for the efficient chemical synthesis. Our current areas of focus include:
1) new synthetic approaches to rare or unknown heterocyclic scaffolds;
2) expanding the versatility of simple inexpensive substrates like dimethylsulfoxide (DMSO) as synthetic building blocks; and
3) use of heterogeneous reagents to enhance procedural efficiency and minimize the environmental impact of organic synthesis.