Brian Coombes, PhD

Brian Coombes, PhD


Chair and Professor

Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences

Canada Research Chair in Infectious Disease Pathogenesis

4N59 Health Sciences Centre
McMaster University
905-525-9140 ext. 22454


  • Microbiological Biochemistry
  • Antimicrobial Research Cell Biology
  • Gene Regulation

The Coombes laboratory investigates the genetics and molecular pathogenesis of human and animal infectious diseases. Coombes lab scientists use genetic, genomic and proteomics techniques to understand how bacterial virulence factors are expressed and function in the context of a host. We use model systems to then understand the complexity of the biological processes affected by these virulence factors, including subversion of the immune system, colonization dynamics and host damage. We have initiated research projects in four major areas that focus on the evolution, mechanisms and host responses to pathogenic processes caused by bacteria.

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