Sara Andres, PhD
- DNA Damage Response and Repair
- Drug Resistant Infections
- Structural Biology
Drug resistant infections continuously challenge all forms of eukaryotic life including humans, plants, and animals. Current antibiotic therapies against bacterial infections include those that damage the bacterial genome, however DNA damage response and repair mechanisms lead to cell survival and drug resistant infections. Our lab is interested in understanding the molecular mechanisms of bacterial DNA damage response and repair through protein-protein and protein-DNA interactions and the role these interactions play in driving the evolution of antimicrobial resistance. We employ structural biology (x-ray crystallography, small-angle x-ray scattering, and atomic force microscopy), biochemistry, and molecular and cell biology to identify unique features of the DNA damage response and repair systems that can be exploited for new therapeutic strategies targeting pathogenic bacteria.